TORPEdO: A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer

Open AccessPublished:November 21, 2022DOI:


      • There is a lack of prospective level I evidence for the use of PBT for most adult cancers including oropharyngeal squamous cell carcinoma (OPSCC).
      • TORPEdO is the UK’s first PBT clinical trial and aims to determine the benefits of PBT for OPSCC.
      • Training and support has been provided before and during the trial to reduce variations of contouring and radiotherapy planning.
      • There is a strong translational component within TORPEdO. Imaging and physics data along with blood, tissue collection will inform future studies in refining patient selection for IMPT.
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